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Three-dimensional vascular imaging of proliferative diabetic retinopathy by Doppler optical coherence tomography.

Department of Ophthalmology, Tokyo Medical University, Ibaraki Medical Center, Ibaraki, Japan; Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan. Electronic address: m-miura@tokyo-med.ac.jp. Computational Optics Group, University of Tsukuba, Ibaraki, Japan. Department of Ophthalmology, Tokyo Medical University, Ibaraki Medical Center, Ibaraki, Japan; Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan. Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan.

American journal of ophthalmology. 2015;(3):528-38.e3
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Abstract

PURPOSE To evaluate the 3-dimensional architecture of neovascularization in proliferative diabetic retinopathy using Doppler optical coherence tomography (OCT). DESIGN Prospective, nonrandomized clinical trial. METHODS Seventeen eyes of 14 patients with proliferative diabetic retinopathy were prospectively studied. Prototype Doppler OCT was used to evaluate the 3-dimensional vascular architecture at vitreoretinal adhesions. RESULTS Proliferative membranes were detected in all eyes with proliferative diabetic retinopathy by standard OCT images. Doppler OCT images detected blood flow by neovascularization of the disc in 12 eyes and neovascularization elsewhere in 11 eyes. Doppler OCT images showed the 3-dimensional extent of new vessels at various stages of neovascularization, and the extent of new vessels could be clearly confirmed at vitreoretinal adhesions. CONCLUSIONS Doppler OCT is useful for the detection and evaluation of the 3-dimensional vascular structure of neovascularization, and can assist in the noninvasive assessment of proliferative diabetic retinopathy.

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Publication Type : Clinical Trial

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